Effect of denosumab switched from bisphosphonates in preventing joint destruction in postmenopausal rheumatoid arthritis patients with anti-cyclic citrullinated peptide antibodies
نویسندگان
چکیده
Abstract Introduction This study aimed to determine the effects of denosumab treatment on joint destruction Japanese females with rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (CCP) antibodies. Materials methods retrospective longitudinal included 56 patients treated 50 bisphosphonate. All participants were positive for anti-CCP also had a history osteoporosis bisphosphonate, which was either continued or switched 60 mg subcutaneous injection every 6 months. To assess progression destruction, hand foot radiographs taken, changes in modified total Sharp score (mTSS), erosion (ERO), space narrowing (JSN) evaluated at 12 months 24 The BMD lumbar spine hip assessed Results At months, there significant differences change ERO ( p = 0.015) mTSS 0.01). Similarly, 0.013) 0.003) In contrast, no difference observed JSN clinical parameters. There femoral neck 0.011) 0.012). Conclusion Denosumab might be effective inhibition bone RA, it potentially contributes prevention destructive switching from bisphosphonate .
منابع مشابه
diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis
objective: anti-cyclic citrullinated peptide (anti-ccp) antibodies are highly specific markers for rheumatoid arthritis (ra) and useful for predicting rheumatoid arthritis (ra) development and progression. we assessed the diagnostic value of anti-ccp antibodies in our patients with ra. materials and methods: anti-ccp antibodies and rheumatoid factor (rf) titers were determined in 247 serum sam...
متن کاملAnti-cyclic citrullinated peptide antibodies and rheumatoid factor in rheumatoid arthritis patients and relatives from Brazil.
OBJECTIVES To evaluate the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies and RF in RA patients and their relatives from Southern Brazil. METHODS Anti-CCP2 and IgM-RF were evaluated in 156 RA patients and 200 relatives. Sera from 100 healthy unrelated individuals were used as control. The anti-CCP2 was detected by ELISA and the IgM-RF using the latex agglutination test....
متن کاملRole of anti cyclic citrullinated peptide antibodies in erosive disease in patients with rheumatoid arthritis.
BACKGROUND & OBJECTIVES Antibodies to cyclic citrullinated peptide (CCP) are a recently described marker in rheumatoid arthritis (RA), which are said to connote aggressive disease. No data on these antibodies are available from India. We undertook this study to evaluate the role of second generation anti CCP antibodies (anti CCP-2) in predicting erosive disease in Indian patients with rheumatoi...
متن کاملThe diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis.
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. The aim of this study was to evaluate the diagnostic value of anti CCP antibodies in patients with RA. This study included three groups; group I: 60 early diagnosed RA patients selected according to the ACR, group II: 30 patients of arthritis other than RA, group III: 10 healthy age and sex matche...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Surgery and Research
سال: 2021
ISSN: ['1749-799X']
DOI: https://doi.org/10.1186/s13018-021-02271-2